Title:
BENG 100: Frontiers of Biomedical Engineering Lecture 12 - Biomolecular Engineering: General Concepts (cont.)
Speaker:
Professor Saltzman
Subject:
controlled release drug delivery system, such as anti-restenosis drug incorporated into stents, and chemotherapeutic drugs in brain implants and microspheres.
Area:
Biomedical Engineering
Type of school:
univerity
School name:
Yale University
Country:
United States
Course language:
English
Course media:
Video
Course duration:
Contributor:
pbp
Comments:
BENG 100: Frontiers of Biomedical Engineering Lecture 12 - Biomolecular Engineering: General Concepts (cont.) Overview:
Professor Saltzman reviews the pharmacokinetic first-order rate equation that can be used to model changes in drug concentration in the blood, as well as its derivation from the law of conservation of mass. The importance of maintaining a drug concentration that is sufficient for therapeutic purpose, but below a toxic level, is emphasized. Since this is directly affected by drug administration method, ways to localize and sustain therapeutic concentrations of drug, such as incorporating in slow-releasing, biocompatible polymers are introduced. Professor Saltzman gave some examples of clinical applications of controlled release drug delivery system, such as anti-restenosis drug incorporated into stents, and chemotherapeutic drugs in brain implants and microspheres.
Reading assignment:
Biomedical Engineering: Bridging Medicine and Technology, in preparation by Mark Saltzman (forthcoming by Cambridge University Press); chapter 14
Summary and Key Concepts: Chapter 14 [PDF]