Title:
BENG 100: Frontiers of Biomedical Engineering Lecture 11 - Biomolecular Engineering: General Concepts
Speaker:
Professor Saltzman
Subject:
pharmacokinetics and pharmacodynamics
Area:
Biomedical Engineering
Type of school:
university
School name:
Yale University
Country:
United States
Course language:
English
Course media:
Video
Course duration:
Contributor:
pbp
Comments:
BENG 100: Frontiers of Biomedical Engineering Lecture 11 - Biomolecular Engineering: General Concepts Overview:
Professor Saltzman starts the lecture with an introduction to pharmacokinetics and pharmacodynamics. Professor Saltzman talks about the concept of dose-response. He introduces different routes of drug administration and how they affect drug distribution and bioavailability (i.e., intravenous, oral, and sublingual routes). First-pass drug metabolism by the liver is also identified as an important source of drug degradation. Finally, modeling the body as a well-stirred vessel, Professor Saltzman explains the first-order rate equation: C = (M0/V)*e-kt, that can be used calculate the amount of drug in the body (M) as a function of time (t) and a rate constant (k); and the equation for drug half-life: t = ln(2/k).
Reading assignment: